These are the 15 U.S. cities where the most Fortune 500 companies are headquartered according to the May 2022 Fortune 500 listing.

| Rank | City | # FORTUNE 500 HQs |
| 1 | New York, NY | 43 |
| 2 | Houston, TX | 21 |
| 3 | Atlanta, GA | 15 |
| 4 | Chicago, IL | 14 |
| 5 | Dallas, TX | 11 |
| 6 (tie) | Irving, TX | 8 |
| 6 (tie) | San Francisco, CA | 8 |
| 8 (tie) | Charlotte, NC | 7 |
| 8 (tie) | Pittsburgh, PA | 7 |
| 8 (tie) | San Jose, CA | 7 |
| 8 (tie) | Seattle, WA | 7 |
| 12 (tie) | Boston, MA | 6 |
| 12 (tie) | Cincinnati, OH | 6 |
| 12 (tie) | Minneapolis, MN | 6 |
| 12 (tie) | Richmond, VA | 6 |